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ssDNA Virus Replication, Virus ssDNA synthesis is initiated by cleavage of the virion sense strand by the virus encoded replication associated protein Rep immediately downstream of the 3 thymidine residue in an absolutely conserved TAATATT AC sequence located in the loop of a potential stem loop structure within the intergenic region
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ssDNA Virus Replication, Replication of DNA viruses DNA Virus Replication strategies General The virus needs to make mRNAs that can be translated into protein by the host cell translation machinery The virus needs to replicate its genome Host enzymes for mRNA synthesis and DNA replication are nuclear except for Poxvirus in cytoplasm and so if a virus is to avail itself of these enzymes it needs to
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ssDNA Virus Replication, Some small viruses carry their genome as single stranded DNA ssDNA molecules These viruses have a simple genome one gene for a viral nucleocapsid protein and another gene for a DNA replication enzyme The virus with a ssDNA genome also faces a serious replication problem in the host cell
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ssDNA Virus Replication, Since a virus is an intracellular parasite it has to operate within limits imposed by the host cell or circumvent these limitations DNA VIRUS REPLICATION STRATEGIES General The virus needs to make mRNAs that can be translated into protein by the host cell translation machinery The virus needs to replicate its genome
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ssDNA Virus Replication, DNA Replication Replication requires expression of at least one virus protein sometimes many DNA is always synthesized 5 3 via semiconservative replication Replication initiates at a de ned origin using a primer The host provides other proteins 4
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ssDNA Virus Replication, Viral replication is the formation of biological viruses during the infection process in the target host cells Viruses must first get into the cell before viral replication can occur Through the generation of abundant copies of its genome and packaging these copies the virus continues infecting new hosts Replication between viruses is greatly varied and depends on the type of genes
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DNA virus Wikipedia
ssDNA Virus Replication, A DNA virus is a virus that has DNA as its genetic material and replicates using a DNA dependent DNA polymerase The nucleic acid is usually double stranded DNA dsDNA but may also be single stranded DNA ssDNA DNA viruses belong to either Group I or Group II of the Baltimore classification system for viruses Single stranded DNA is usually expanded to double stranded in infected cells
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